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Police have questioned a 25-year-old man in relation to a hit-and-run crash which left a cyclist in hospital.
A 34-year-old man was hit by a vehicle on Back Lane close to the junction with B6259 Morecambe Road, Clitheroe, at around 1am last night.
The driver stopped but officers say they are unsure if he was involved in the collision.
In a separate incident, officers have also released an appeal for information on a hit-and-run collision in East Park at around midnight.
The victim, a 45-year-old man, was hit by a vehicle which left the scene and is described as being dark-coloured and registration number 669 JW.
Anyone with information should contact police on 101, quoting incident number 0316 of November 3. Information can also be passed on anonymously to Crimestoppers on 0800 555 111.A slow metalloendopeptidase mediates the rapid inactivation of osteopontin in a living human osteosarcoma cell line.
We have previously demonstrated that the biological effect of osteopontin (OPN) depends on the structure of the Arg-Gly-Asp (RGD) sequence. OPN can be rapidly cleaved after the Arg residue, in a pH-independent process, by a metalloendopeptidase that is present in the conditioned medium of various human cell lines. The osteosarcoma cell line HOS was used to evaluate the effects of structural variation of the RGD motif on the inactivation of cell-associated OPN. A cell-permeable RGD-containing peptide, the LysRADK motif, failed to accelerate the inactivation of cell-associated OPN as determined by enzyme-linked immunosorbent assay and an OPN-specific ELISA. Replacement of the RGD motif by a ProGlyPro sequence conferred no protection against OPN inactivation, as measured by both assays. In contrast, substitution of the 0b46394aab
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